Thank you for all your work to keep us informed. One could get "lost" for days clicking and reading on the headlines of Medicine (Un)Censored.

Forgive my temporary ignorance on the matter, but one of the highlights of your links was learning of "The Wayback Machine", which was new to me - the Internet never forgets, LOL.

Yeah, but botched, as in error or incompetence?

To put so much effort into it, and get results so wrong, and so nicely politically correct, means prior intent.
Not a conspiracy, the author needed no inside knowledge of the postmodernist criteria for acceptance of papers, even at (once) eminent journals such as The Lancet and the New England Journal of Medicine.

The benefits of hydroxychloroquine helped me to piece together information about how COVID-19 functions. What is listed below is part of an incomplete background that I will eventually put on the web site of my new company (Chem-Free Solutions) that is partly described at the following site and its oldest comment (a sales pitch):
https://www.galtsgulchonline.com/post...

The French health minister reported that an infectious disease doctor from southwest France had "cited four cases of young patients with COVID-19 and no underlying health problems who went on to develop serious symptoms after using non-steroidal anti-inflammatory drugs (NSAIDs) in the early stage of their symptoms."
(https://www.bmj.com/content/368/bmj.m.... Actemra is designed to prevent cytokine storms by blocking interleukin 6 (IL-6). At about the same time, anecdotal reports of reduction in symptoms by hydroxychloroquine surfaced as well. Hydroxychloroquine has been used to treat lupus, a rheumatoid inflammatory arthritis autoimmune disease, for over half a century. Hydroxychloroquine decreases T helper 17 (Th 17) cytokines IL-6, IL-17, and IL-22 (Cruz da Silva et al., 2013) and has protective effects against accelerated atherosclerosis in lupus patients (Floris et al., 2018). The IL-6 pathway (JAK-STAT) increases corticosteroid production in adrenal glands to help stop the immune response and is Involved in C-reactive protein reactions and clotting

COVID-19 targets the angiotensin-converting enzyme 2 (ACE2) to enter epithelial cells (Al Ghatrif et al., 2020), but also plays an anti-inflammatory role in renin-angiotensin signaling (RAS).

Earlier I stated that the antigen is digested by the ubiquitin proteasome system where MHC-1 is presented to the cytotoxic T cells. Causing a failure in the ubiquitin proteasome system is a possible path for long term pathogenic attack, as compromise in this system leads to an overabundance of undigested proteins that have led to Alzheimer's disease (Kotilinek et al.). Kotilinek et al.'s results "predict that the predominant efficacy of NSAIDs" on Alzheimer's disease "will be found in individuals with normal levels of COX-2, prior to increases in COX-2 due to inflammation or glutamate". The ubiquitin proteasome system has also been the target of anti-cancer drugs (Soave et al.) and autoimmune diseases like lupus as well (Bulatov et al.).

If MHC-1 binds too well to a foreign protein (e.g. gluten in Celiac's disease), then one gets an overexpressed T cell response and is said to be intolerant to that foreign protein. Other than those living in assisted living facilities, most people who are dying or are hospitalized from COVID-19 are exhibiting symptoms of Type 3 hypersensitivity. Type 3 hypersensitivity is common in people with persistent gut and/or kidney inflammation.

My family has a very involved history of odd immune responses. Piecing together this puzzle has helped me figure out how improper process control of eosinophils, the least understood of the immune cells (and if you are healthy, the type of cell in lowest concentration) has led to a myriad of conditions (cold-induced asthma, eczema, eosinophilic esophagitis, food allergies and intolerances, allergies induced by anaethesia, and even Alzheimer's disease). I think that I am on the cusp of understanding how all of this is related to failures in the ubiquitin proteasome system.

Causing a failure in the ubiquitin proteasome system is a possible path for long term pathogenic attack, as compromise in this system leads to an overabundance of undigested proteins that have led to Alzheimer's disease (Kotilinek et al.). Kotilinek et al.'s results "predict that the predominant efficacy of NSAIDs" on Alzheimer's disease "will be found in individuals with normal levels of COX-2, prior to increases in COX-2 due to inflammation or glutamate". The ubiquitin proteasome system has also been the target of anti-cancer drugs (Soave et al.) and autoimmune diseases like lupus as well (Bulatov et al.). What helped me connect all of this was how hydroxychloroquine has long been used as a treatment for lupus, a form of rheumatoid arthritis. From Ge et al, in https://www.pnas.org/content/pnas/113..., "pretreatment of eosinophils with MG132, a proteasome inhibitor that inhibits degradation of ubiquitin-tagged proteins", regulates Galectin-1, which appears to regulate eosinophil function, airway inflammation, and asthma.

ThanQ Lucky 👍🏼

Read it, saw that it was a botched job...they can't even cheat right.
GB did a rant on it too and now the Who? has thought twice...if that's even possible for those creatures.
100 Scientist spoke up and called em out.

"who actually put the numbers together and who paid?"
It looks familiar.
Similar to some paperwork about Russian connections to a campaign for President. Recently exposed as completed contrived and illegal.
Just my opinion, but the same pattern is being repeated. Perhaps by the same or allied interests.

Thanks for the links and the research, Lucky. 👍

The Lancet is very political...for whatever reason. Am very familiar with some of their shenanigans...

...and if you act now, we’ll include global pandemic! FREE! For only $6 trillion! Side effects include your brain turning to mush and pathological urges to riot with fascists.

From the people who brought you global warming, global cooling and global staying the same.

I have just come across this site-
https://www.medicineuncensored.com/ run by James Todaro, MD.
The site is well worth a look at to check on the latest hydroxychloroquine stories and, hopefully, proper scientific papers.
This deals with the Lancet paper-
https://www.medicineuncensored.com/a-...

There is a company behind it, 'out of thin air', 2 months old, of the people in the company, looks like only five, only one is a medic. the others have varied backgrounds. The company name is Surgisphere.
Surgisphere’s only other peer-reviewed publication is 'Cardiovascular, Drug Therapy, and Mortality in Covid-19' that was published on May 1, 2020 in The New England Journal of Medicine. See my post above for the web address.

Reminder- this paper was peer reviewed.
Peer review is nowadays seen as mates reviewed,
but Todaro cannot even find any mates of the author.

[macrolide = antibiotic]

A cautious person could think that these two odd papers, both now retracted, were put out with the intention to falsely claim that HCQ does not work, and is dangerous. Whoever put them out has concealed their tracks, data sources, and funding. They had a realistic view of the integrity of peer review at least on topics where political bias can override scientific evidence.

There is also
https://www.nejm.org/doi/full/10.1056...
claim that HCQ promotes cardiovascular disease - wrong.

The story was broken by France Soir, The Guardian ran it well down inside but claims the credit.
Journals- NEJM and Lancet.
Both of the supposedly scientific papers were peer reviewed, reported on data manipulations not actual studies, the data is un-trackable. The company behind the papers is peculiar, who actually put the numbers together and who paid? not yet known.

The Lancet, once a prestigious journal of medicine has under its current board and (especially) editor, a record of blatant political interference. eg. -- editorial, 16 May
“Americans must put a president in the White House come January 2021 who will understand that public health should not be guided by partisan politics.” [My comment- gasp!]

Good reports on-
https://wattsupwiththat.com/2020/06/0... and
http://joannenova.com.au/2020/06/huge...

Good background on-
https://wattsupwiththat.com/2020/06/0...
if you want to be up well informed, warning, comments are of a high standard and could take an hour just to read.

Why dinos do not trust polls.

When 99% of the mainstream media constantly lie about Trump and twist everything he does and says, there is a high probability of brainwashing on those who still accept the MSM propaganda as truth.
That is a major flaw in universal suffrage.

I have people in my family that would vote for an aardvark if it had a "D" after its name, especially if it was a cute aardvark.

This scenario is happening a lot. Since the ratings of the televised talking heads seem to be tanking, I wonder if more and more people are catching on, but then you see "poles" of Biden beating Trump... lots of confusion out there.

And about half the registered voters will believe whatever they are told.
Those who CAN think must provide rational leaders to guide those who can't or the useful idiots will be the wolves who decide who is for dinner.

Should Trump say a daytime cloudless sky is blue, Fake News will say it is green with a scientific study conducted by TDS-deranged "experts" to prove it while televised panels of talking heads will discuss how stupid Trump is.